Diacylglycerol kinase

By Targets:	DGK (6) 5-HT Receptor (2) Apoptosis (1) Biochemical Assay Reagents (1) ERK (1) Liposome (1) p38 MAPK (1) PKC (6)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (1)

Targets Recommended: DGK Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107613

R 59-022 1 Publications Verification DKGI-I; Diacylglycerol kinase inhibitor I	PKC 5-HT Receptor	Inflammation/Immunology
R 59-022 (DKGI-I) is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates *protein kinase* C (PKC)*. R 59-022 potentiates thrombin-induced diacylglycerol* production in platelets and inhibits phosphatidic acid production in neutrophils .

HY-107613A

R 59-022 hydrochloride 1 Publications Verification DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride	PKC 5-HT Receptor	Infection Inflammation/Immunology Cancer
R 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC₅₀: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates *protein kinase* C (PKC)*. R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol* production in platelets and inhibits phosphatidic acid production in neutrophils .

HY-108355

R59949	PKC	Cancer
R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC₅₀ of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol .

HY-126599

Cochlioquinone A Luteoleersin	DGK	Cancer
Cochlioquinone A is a ATP-competive **diacylglycerol kinase inhibitor (K_i*: 3.1 μM). Cochlioquinone A can be isolated from Drechslera sacchari* .

HY-143212

18:0-22:6 DG 1-Stearoyl-2-docosahexaenoyl-sn-glycerol	Liposome p38 MAPK	Others
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol that can bind to RasGRP and modulate MAP kinases activation .

HY-100960

Dioctanoylglycol Ethylene glycol dicaprylate; Ethylene glycol dioctanoate; Ethylenedioctanoate
Dioctanoylglycol (Ethylene glycol dicaprylate), a diacylglycerol analog, is a diacylglycerol kinase (DGK) inhibitor (K_i of 58 μM) .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	PKC	Cancer
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent *Protein kinase* C (PKC)** inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

HY-115769

1,2-Didecanoylglycerol	PKC	Endocrinology
1,2-Didecanoylglycerol, a synthetic diacylglycerol, is metabolized by platelets to 1,2-didecanoylphosphatidic acid (PA₁₀) and activates *protein kinase* C (PKC)** .

HY-153343

BAY 2965501	DGK	Cancer
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .

HY-156572

DGKζ-IN-3

Others Cancer

DGKζ-IN-3 is a DGK-zeta-inhibitor. DGKζ-IN-3 is used in liquid and solid cancer and other diacylglycerol kinase zeta (DGK-ζ) regulation of diseases .

DGKζ-IN-3	Others	Cancer
DGKζ-IN-3 is a DGK-zeta-inhibitor. DGKζ-IN-3 is used in liquid and solid cancer and other diacylglycerol kinase zeta (DGK-ζ) regulation of diseases .

HY-153343A

(S)-BAY 2965501	DGK ERK	Cancer
(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343). BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .

HY-131648

1-Oleoyl-2-acetyl-sn-glycerol	PKC	Metabolic Disease
1-Oleoyl-2-acetyl-sn glycerol is a synthetic, cell permeable diacylglycerol analog. 1-Oleoyl-2-acetyl-sn glycerol activates calcium-dependent protein kinase C (PKC) and induces the superoxide-production.

HY-148174

JNJ-3790339	DGK	Cancer
JNJ-3790339, a Ritanserin (HY-10791) analog, is a potent and selective diacylglycerol kinase (DGKα) inhibitor with an IC₅₀ of 9.6 μM. JNJ-3790339 has induction of toxicity in malignant cells, and improves ability to upregulate T cell activation .

HY-149874

BMS-502	DGK	Inflammation/Immunology
BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC₅₀ of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research .

HY-117115

1,2-Dihexanoyl-sn-glycerol	Biochemical Assay Reagents	Others
1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.

HY-121638

CU-3	Apoptosis DGK	Inflammation/Immunology Cancer
CU-3 is the racemate of (5Z,2E)-CU-3. (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC₅₀ value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K_m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells .

HY-149489

JH-131e-153	Others	Neurological Disease
JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases .

Cat. No.	Product Name	Type

HY-143212

18:0-22:6 DG 1-Stearoyl-2-docosahexaenoyl-sn-glycerol	Drug Delivery
18:0-22:6 DG (1-Stearoyl-2-docosahexaenoyl-sn-glycerol) is a diacylglycerol that can bind to RasGRP and modulate MAP kinases activation .

HY-117115

1,2-Dihexanoyl-sn-glycerol	Biochemical Assay Reagents
1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126599

Cochlioquinone A Luteoleersin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	DGK
Cochlioquinone A is a ATP-competive **diacylglycerol kinase inhibitor (K_i*: 3.1 μM). Cochlioquinone A can be isolated from Drechslera sacchari* .

HY-118442

Sphingosine (d14:1) Tetradecasphing-4-enine	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Cancer	PKC
Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent *Protein kinase* C (PKC)** inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .

Species:	Human (2)
Tag:	His (2) SUMO (1) Myc (2)
Source:	E. coli Cell-free (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P702617

	DGKA Protein, Human (sf9, His, Myc) 80 kDa Diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK alpha; DGK-alpha; dgkA; DGKA_HUMAN; Diacylglycerol kinase alpha; Diacylglycerol kinase; alpha 80kDa; Diglyceride kinase alpha; MGC12821; MGC42356; OTTHUMP00000242836; OTTHUMP00000242955; OTTHUMP00000244046	Human	Sf9 insect cells

HY-P702262

	DGKE Protein, Human (Cell-Free, His, SUMO, Myc) Diacylglycerol kinase epsilon; Diglyceride kinase epsilon; DGK-epsilon	Human	E. coli Cell-free
	DGKE protein is a membrane-bound diacylglycerol kinase that balances cell signaling by converting diacylglycerol (DAG) to phosphatidic acid (PA). As a central switch in signaling pathways, DGKE has opposite effects on various biological processes and significantly promotes complex lipid biosynthesis. DGKE Protein, Human (Cell-Free, His, SUMO, Myc) is the recombinant human-derived DGKE protein, expressed by E. coli Cell-free , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of DGKE Protein, Human (Cell-Free, His, SUMO, Myc) is 567 a.a., with molecular weight of 83.9 kDa.


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Diacylglycerol kinase

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